Molecular Analysis and Therapeutic Application. Molecular Targeting for Breast Cancer Treatment.

Molecular pathways: targeting inhibitor of apoptosis proteins in cancer--from molecular mechanism to therapeutic application.

Inhibitor of apoptosis (IAP) proteins play a critical role in the control of survival and cell death by regulating key signaling events such as caspase activation and NF-κB signaling. Because aberrantly high expression of IAP proteins represents a frequent oncogenic event in human cancers, therapeutic targeting of IAP proteins is considered as a promising approach. Several small-molecule pharma...

Preclinical and Clinical Developments in Molecular Targeting Therapeutic Strategies for Breast Cancer

Molecular imaging approaches in the diagnosis of breast cancer: A systematic review and meta-analysis

Introduction:The accuracy of positron emission tomography with computed tomography (PET/CT), positron emission mammography (PEM), and breast specific-gamma imaging (BSGI) in diagnosing breast cancer has never been systematically assessed, the present systematic review was aimed to address this issue.  Methods:PubMed, Scopus and EMBASE were searched for st...

breast cancer: genetics, risk factors, molecular pathology and treatment

breast cancer within incident of one million new cases each year has become one of the most common malignancies and leading cause of death among females. this disease is comprised of about 18% of women cancers. the availability of early detection and improved treatments may decrease the mortality rates which reflected in the united states and many other western countries. breast cancer in over ...

Molecular Pathways Molecular Pathways: Targeting PARP in Cancer Treatment

Poly (ADP-ribose) polymerases (PARP) are a family of nuclear protein enzymes involved in the DNA damage response. The role of PARP-1 in base excisional repair has been extensively characterized. More recent in vitro studies additionally implicate a role for PARP-1 in facilitating homologous recombination and nonhomologous end-joining. The more faithful process of homologous recombination repair...